Table 6.
Effect of Tadalafil on Maximum Urinary Flow Rate and Post-Voiding Residual Urine Volume
| Observation Period | Measured Value | Mean Change From Baseline | |||||
|---|---|---|---|---|---|---|---|
| n | Mean | SD | n | Mean | 95% CI | ||
| Qmax (mL/s) | Baseline | 333 | 13.4 | 6.83 | − | − | − |
| 3M | 213 | 14.0 | 5.7 | 124 | 0.50 | −0.62 to 1.61 | |
| 6M | 217 | 13.7 | 6.29 | 118 | 0.36 | −0.94 to 1.66 | |
| 12M | 176 | 13.5 | 5.88 | 99 | −0.43 | −1.91 to 1.04 | |
| 18M | 159 | 13.8 | 5.98 | 83 | 1.01 | −0.19 to 2.21 | |
| LOCF | 578 | 11.7 | 6.52 | 236 | −0.65 | −1.53 to 0.24 | |
| PVR (mL) | Baseline | 1006 | 45.9 | 65.7 | − | − | − |
| 3M | 545 | 37.8 | 54.1 | 484 | −12.7 | −17.9 to –7.6 | |
| 6M | 550 | 42.7 | 70.7 | 486 | −8.0 | −13.3 to –2.6 | |
| 12M | 473 | 37.4 | 55.5 | 409 | −9.0 | −14.4 to –3.7 | |
| 18M | 427 | 33.9 | 48.8 | 371 | −9.8 | −15.2 to –4.5 | |
| LOCF | 848 | 41.8 | 72.8 | 699 | −7.6 | −12.5 to –2.7 | |
Abbreviations: CI, confidence interval; LOCF, last observation carried forward; M, months; n, number of patients analyzed; PVR, post-voiding residual urine volume; Qmax, maximum urinary flow rate; SD, standard deviation.