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. 2020 May 4;15:3137–3160. doi: 10.2147/IJN.S247935

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© 2020 Sun et al.

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Stability of PAE in simulated biological samples. (A) Stability of PAE in artificial gastric juice; (B) stability of PAE in artificial intestinal juice; (C) stability of PAE in the liver microsomes metabolic system in vitro; (D) first-order metabolic half-lives of PAE in different simulated biological samples. Data are expressed as mean ± SD, n = 3.

Notes: The differences between groups were performed using Student’s t-test or one-way analysis of variance (ANOVA). ***p < 0.0001 was considered statistically significant.

Abbreviations: PAE, paeonol; NADPH, nicotinamide adenine dinucleotide phosphate.