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. Author manuscript; available in PMC: 2021 May 8.
Published in final edited form as: Circ Res. 2020 Mar 5;126(10):e80–e96. doi: 10.1161/CIRCRESAHA.119.316288

Figure 1. Glucose induced ROS production without contractility alteration.

Figure 1

(A) Representative mouse cardiomyocyte loaded with DCF. Scale bar is 20μm. (B) DCF fluorescence change in response to Hi-Glu in myocytes. (C-D) Quantification of DCF slope in presence of Hi-Glu/ThmG with KN93 and OSMI-1, normalized to the slope prior to HiGlu or ThmG exposure. (E) Representative fractional shortening of unloaded cardiomyocytes.(F) Peak fractional shortening with Hi-Glu perfusion at 3 minutes. (G-H) Mean fractional shortening in control NT or with Hi-Glu or ThmG. (Animal number N is indicated in bars, while each individual myocyte (n) is shown as a data point, ***P<0.001, ****P<0.0001).