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. Author manuscript; available in PMC: 2021 May 8.
Published in final edited form as: Circ Res. 2020 Mar 5;126(10):e80–e96. doi: 10.1161/CIRCRESAHA.119.316288

Figure 8. ROS generation and SR Ca2+ handling in hiPSC-CMs.

Figure 8

(A) Representative confocal images of hiPSC-CMs expressing adenovirus carried cyto-Grx redox sensor. (B) Average ratio metric change with Hi-Glu. (C) Hi-Glu induced ROS production could be inhibited by KN93 and OSMI-1, respectively. (D) Line-scan image of Ca2+ transients and LCRs. B, Transient; L, LCRs. (E) No change of spontaneous transient frequency with Hi-Glu. (F) Hi-Glu induced LCRs in hiPSC-CMs. (*P<0.05, **P<0.01, ***P<0.001)