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. 2020 May 8;3:225. doi: 10.1038/s42003-020-0960-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–d Multi-electrode array recordings conducted during the day (ZT4-6) or night (ZT16-18) reveal that NTS neurons increased nocturnal responsiveness to (a) CCK, (b) elevated glucose, (c) ghrelin, and (d) orexin A. Pie charts represent the proportion of NTS recording locations responding through activation (orange), inhibition (light green) or no change in firing activity (grey). Bars represent the amplitude of drug-evoked excitation or inhibition (*p < 0.05, ***p < 0.001 t test or Mann–Whitney test). Multi-unit activity traces showing representative responses to drug application during the day or night are presented below. e–g Temporal variation in gene expression for metabolic receptors in the NTS sampled at CT0, 6, 12, and 18. Data are plotted relative to the values at CT0. Orexin receptor gene expression (Hcrtr1 and Hcrtr2) varied across these time points. *p < 0.05, one-way ANOVAs or Kruskal–Wallis tests.