Table 3. Multivariable Cox model of prognostic factors for PFS and OS.
| Factors | Multivariable (PFS)a | Multivariable (OS)b | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| pN stage (Model 1) | 1.774 | 1.399–2.250 | <0.001 | 1.568 | 1.148–2.144 | 0.005 | |
| 2018 FIGO stage (Model 2) | <0.001 | 0.003 | |||||
| 0 | Reference | ||||||
| 1 | 1.687 | 1.322–2.152 | <0.001 | 1.489 | 1.080–2.052 | 0.015 | |
| 2 | 2.644 | 1.775–3.940 | <0.001 | 2.381 | 1.407–4.028 | 0.001 | |
| PLN (Model 3) | <0.001 | <0.001 | |||||
| 0 | Reference | Reference | |||||
| 1 | 1.582 | 1.230–2.035 | <0.001 | 1.314 | 0.938–1.841 | 0.112 | |
| 2 | 2.818 | 2.019–3.934 | <0.001 | 2.989 | 1.956–4.567 | <0.001 | |
| NLN (Model 4) | 0.066 | 0.202 | |||||
| 1 | Reference | Reference | |||||
| 2 | 0.557 | 0.351–0.882 | 0.013 | 0.558 | 0.306–1.017 | 0.057 | |
| 3 | 0.550 | 0.342–0.885 | 0.014 | 0.538 | 0.289–1.000 | 0.050 | |
| 4 | 0.543 | 0.345–0.856 | 0.009 | 0.525 | 0.290–0.951 | 0.034 | |
| LNR (Model 5) | <0.001 | <0.001 | |||||
| 0 | Reference | Reference | |||||
| 1 | 1.141 | 0.559–2.329 | 0.718 | 1.348 | 0.546–3.328 | 0.518 | |
| 2 | 1.605 | 1.228–2.097 | 0.001 | 1.211 | 0.840–1.744 | 0.305 | |
| 3 | 2.368 | 1.753–3.199 | <0.001 | 2.525 | 1.721–3.704 | <0.001 | |
| LODDS (Model 6) | <0.001 | <0.001 | |||||
| 1 | reference | reference | |||||
| 2 | 1.363 | 0.979–1.897 | 0.067 | 1.050 | 0.658–1.674 | 0.839 | |
| 3 | 1.521 | 1.085–2.134 | 0.015 | 1.222 | 0.776–1.925 | 0.387 | |
| 4 | 2.284 | 1.712–3.048 | <0.001 | 2.392 | 1.651–3.464 | <0.001 | |
| Different LN staging systems (Model 7) | |||||||
| pN stage | 1.395 | 0.664–2.929 | 0.379 | 2.259 | 0.670–7.611 | 0.189 | |
| 2018 FIGO Stage | 1.131 | 0.738–1.733 | 0.573 | 1.056 | 0.609–1.832 | 0.846 | |
| PLN | 1.497 | 0.957–2.342 | 0.077 | 1.835 | 1.003–3.357 | 0.049 | |
| NLN | 1.045 | 0.929–1.174 | 0.464 | 1.067 | 0.914–1.247 | 0.412 | |
| LNR | 1.069 | 0.634–1.802 | 0.801 | 1.036 | 0.504–2.130 | 0.924 | |
| LODDS | 1.082 | 0.802–1.460 | 0.606 | 1.239 | 0.828–1.853 | 0.298 | |
a, PFS adjusted for: menopausal status, FIGO stage [2009], tumor diameter (cm), depth of myometrial invasion, LVSI, parametrial invasion, vaginal margin invasion, adjuvant therapy. b, OS adjusted for: FIGO stage [2009], tumor diameter (cm), depth of myometrial invasion, LVSI, parametrial invasion, vaginal margin invasion, adjuvant therapy. PFS, progression-free survival; OS, overall survival; HR, hazard ratios; CI, confidence intervals; FIGO, Federation of Gynecology and Obstetrics; LVSI, lymph-vascular space invasion; PLN, positive lymph nodes; NLN, negative lymph nodes; LNR, lymph node ratio; LODDS, log odds of positive nodes; LN, lymph node.