Table 1. Univariate and multivariate Cox proportional hazards analysis for DFS in patients with stage I NSCLC of the training cohort.
| Factors | Number | DFS | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||||
| HR | 95% CI | P value | HR | 95% CI | P value | |||
| Age (years) | ||||||||
| <55 | 68 | 1.000 | ||||||
| ≥55 | 149 | 1.581 | 0.945–2.642 | 0.081 | ||||
| Sex | ||||||||
| Male | 144 | 1.000 | ||||||
| Female | 73 | 0.721 | 0.440–1.183 | 0.196 | ||||
| Surgery procedures | ||||||||
| Lobectomy | 183 | 1.000 | ||||||
| Sublobectomy | 34 | 1.357 | 0.774–2.378 | 0.287 | ||||
| TNM-stage | ||||||||
| IA | 89 | 1.000 | ||||||
| IB | 128 | 1.744 | 1.102–2.760 | 0.017 | 1.627 | 1.009–2.623 | 0.046 | |
| VPI | ||||||||
| No | 150 | 1.000 | ||||||
| Yes | 67 | 0.953 | 0.591–1.538 | 0.845 | ||||
| Smoking status | ||||||||
| No | 109 | 1.000 | ||||||
| Yes | 108 | 1.267 | 0.819–1.963 | 0.288 | ||||
| Histology | ||||||||
| Adeno | 136 | 1.000 | ||||||
| Non-adeno | 81 | 1.432 | 0.911–2.251 | 0.12 | ||||
| Macrophages immunoscore | ||||||||
| Low (score 0.1) | 132 | 1.000 | 1.000 | |||||
| Intermediate (score 2.3) | 57 | 5.115 | 2.997–8.732 | <0.001 | 4.451 | 2.583–7.670 | <0.001 | |
| High (score 4) | 28 | 13.938 | 7.714–25.184 | <0.001 | 10.965 | 5.742–20.939 | <0.001 | |
| CA153, U/mL | ||||||||
| ≤25 | 198 | 1.000 | ||||||
| >25 | 19 | 0.717 | 0.290–1.774 | 0.472 | ||||
| CEA, U/mL | ||||||||
| ≤5 | 135 | 1.000 | ||||||
| >5 | 82 | 0.961 | 0.610–1.516 | 0.865 | ||||
| NSE, U/mL | ||||||||
| ≤12.5 | 188 | 1.000 | ||||||
| >12.5 | 29 | 0.673 | 0.324–1.397 | 0.288 | ||||
| Lymphocytes | – | 0.762 | 0.561–1.033 | 0.080 | ||||
| Monocytes | – | 0.991 | 0.886–1.107 | 0.867 | ||||
| Neutrophils | – | 1.005 | 0.983–1.028 | 0.645 | ||||
| Platelets | – | 1.000 | 0.998–1.002 | 0.837 | ||||
| White blood cells | – | 0.992 | 0.934–1.050 | 0.746 | ||||
| LMR | ||||||||
| ≤3.6 | 52 | 1.000 | 1.000 | |||||
| >3.6 | 165 | 0.279 | 0.127–0.609 | 0.001 | 0.319 | 0.142–0.717 | 0.006 | |
| NMR | ||||||||
| ≤4.9 | 127 | 1.000 | ||||||
| >4.9 | 90 | 0.926 | 0.591–1.451 | 0.737 | ||||
| NLR | ||||||||
| ≤3.0 | 134 | 1.000 | ||||||
| >3.0 | 83 | 0.722 | 0.454–1.147 | 0.168 | ||||
| PLR | ||||||||
| ≤154.0 | 201 | 1.000 | ||||||
| >154.0 | 16 | 1.921 | 0.960–3.845 | 0.065 | ||||
CA153, carbohydrate antigen 153; CEA, carcinoembryonic antigen; NSE, neuron-specific enolase; LMR, lymphocyte-to-monocyte ratio; NLR, neutrocyte-to-lymphocyte ratio; NMR, neutrocyte-to-monocyte ratio; PLR, platelet-to-lymphocyte ratio.