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. 2020 Apr;8(7):499. doi: 10.21037/atm.2020.03.194

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Schematic representation of TNBC molecular subtypes. This figure shows the association of the transcriptomic TNBC subtypes with other tumor characteristics. The BLIS subtype is correlated with enrichment of HRD mutation signature and high chromosomal instability. The LAR subtype and MES subtype present high frequency of PI3K pathway mutations. The IM subtype is characterized by high immune infiltration and good prognosis. TNBC, triple-negative breast cancer; HRD, homologous recombination deficiency; HER2, human epidermal growth factor receptor 2.