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. 2020 Apr;8(7):499. doi: 10.21037/atm.2020.03.194

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Transformation of precision medicine patterns for TNBC. This figure shows the evolution of precision treatment paradigm for TNBCs from biomarker-based targeted therapy to subtyping-based targeted therapy. The subtyping-based paradigm provides deeper insight to the molecular essence of patient tumors and contributes to more efficient target identification and drug development. TNBC, triple-negative breast cancer; HRD, homologous recombination deficiency; PD-1, programmed Cell Death 1; PD-1, programmed Cell Death ligand 1; AR, androgen receptor.