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. 2020 Apr;8(7):480. doi: 10.21037/atm.2020.03.28

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Changes of Akt1/GSK-3β pathway treated by dezocine at different concentrations in protein level. (A,B) GSK-3β and Akt1 phosphorylation in HePG2 cells shared diverse changes after being treated by dezocine in 2 and 8 µg/mL, while HIF-1α and C-myc didn’t have statistically significant difference. (C,D) GSK-3β and Akt1 phosphorylation in Hep 3B cells shared diverse changes after being treated by dezocine in 2 and 8 µg/mL, while HIF-1α and C-myc didn’t have statistically significant difference. Data are represented as means ± SEM, n=3. *, P<0.05 vs. cells treated without dezocine; ^#P>0.1 vs. cells treated without dezocine.