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. 2020 Apr;8(7):446. doi: 10.21037/atm.2020.03.163

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Figure S5 — Comparison between TMS55 and TMB in predicting survival in non-ICI-treated patients. (A) Forest plot of the comparison between TMS55 and TMB as biomarkers for patients without immunotherapy by cancer type. For TMS55, HRs and P values were compared between the TMS >5 and TMS =0 groups. For TMB, HRs and P values were compared between the top 10% and bottom 80% within each histology group. (B) Kaplan-Meier curve of pan-cancer patients divided into the bottom 80%, top 10-10% and top 10% TMB subgroups within each histology group. (C) Kaplan-Meier curve of pan-cancer patients divided into the bottom 80%, top 10-10% and top 10% TMS55 subgroups within each histology group. (D) Kaplan–Meier curve of pan-cancer patients divided into the TMS55 >5, 1≤ TMS55 ≤5, and TMS55 =0 groups. (E) Kaplan–Meier curve of pan-cancer patients divided into the bottom 80% and top 20% TMB subgroups within each histology group. (F) Kaplan-Meier curve of pan-cancer patients divided into the bottom 80% and top 20% total TMS subgroups within each histology group. Generally, a high TMS55, total TMS and TMB predicted poor OS in several cancer types.