Table 2. Comparison of TMS55 and TMB as prognostic biomarkers in pan-cancer.

Cancer type	TMB				TMS55
	TMB cutoff (top 10%)	HR (95% CI)	P value		TMS55 cutoff	HR (95% CI)	P value
Bladder	24.5	0.43 (0.20–0.95)	0.082		5	0.34 (0.15–0.74)	0.014
Breast	6.8	0.68 (0.20–2.30)	0.013		1	0.66 (0.24–1.84)	0.048
Colorectal	68.8	0.82 (0.32–2.09)	0.011		5	0.24 (0.09–0.62)	0.005
Esophagogastric	13.9	0.46 (0.16–1.31)	0.323		5	0.46 (0.13–1.61)	0.462
Glioma	8.2	0.83 (0.36–1.94)	0.379		5	0.91 (0.28–2.87)	0.803
Head and neck	12.2	0.60 (0.24–1.50)	0.013		5	0.53 (0.12–2.24)	0.500
Non-small cell lung	45.7	0.32 (0.17–0.59)	2.65×10−4		5	0.26 (0.14–0.49)	4.80×10−5
Melanoma	20.2	0.52 (0.24–1.12)	0.153		5	0.43 (0.26–0.72)	9.76×10−4
Renal cell	7.8	0.70 (0.27–1.76)	0.751		1	0.51 (0.26–1.01)	0.100
Unknown primary	22.4	0.51 (0.12–2.17)	0.211		5	0.28 (0.06–1.22)	0.204
Pan-cancer	–	0.52 (0.40–0.69)	1.41×10−6		–	0.30 (0.23–0.39)	6.30×10−20