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. 2020 Apr;8(7):459. doi: 10.21037/atm.2020.03.108

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Sam68 promotes CRC cells proliferation by regulating aerobic glycolysis. (A) The overexpression of Sam68 was determined by Western blotting. (B,C) The pyruvate kinase activity and lactate concentration were measured in CRC cells transfected with pcDNA3.1-Sam68 or pcDNA3.1. (D) Cell proliferation with Sam68-overexpressing HCT116 and RKO cells was measured by CCK8 assays. (E) The knockdown efficiency of Sam68 siRNA was determined by Western blotting. (F,G) The effect of Sam68 knockdown on the pyruvate kinase activity and lactate production in CRC cells. (H) Cells proliferation in the silence of Sam 68-HCT116 and RKO cells was measured using CCK8 assays. *P<0.05, **P<0.01, ***P<0.001. CRC, colorectal cancer; CCK8, cell counting Kit 8.