Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr;8(7):459. doi: 10.21037/atm.2020.03.108

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

PMC Copyright notice

Sam68 is associated with PKM2 mRNA to affect glucose metabolism. (A) The binding of Sam68 to PKM2 mRNA in CRC cells transfected with Sam68-HA performed by RIP assays. (B) Predicted Sam68-binding region with PKM2 mRNA by CatRAPID omics (http://s.tartaglialab.com/). (C) Sam68-ΔKH mutant binding domain to PKM2 mRNA. (D) Sam68-G178E mutant binding domain to PKM2 mRNA. (E) Sam68 binding domain to PKM2 mRNA with the ATAA deletion. (F) The PKM2 mRNA levels analysis with overexpression of Sam68 in the cytoplasm. (G) The PKM2 protein levels in ectopic expression of Sam68 cells. **P<0.01. PKM2, pyruvate kinase muscle 2; CRC, colorectal cancer.