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. 2020 Apr;8(7):459. doi: 10.21037/atm.2020.03.108

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Sam68 promotes PKM2 splicing from PKM. (A) Diagrammatic sketch of PKM splicing assay with PstI digestion protocol. (B) PKM splicing assays in Sam68-depleted HCT116 cells. (C) The effects of the silence of sam68 on PKM splicing by qRT-PCR. (D) PKM splicing assays in Sam68-overexpressing HCT116 cells. (E) The effects of the Sam68 overexpression on the PKM splicing were investigated by qRT-PCR. *P<0.05, **P<0.01, ***P<0.001. PKM2, pyruvate kinase muscle 2.