Table 6. Incidence and adjusted hazard ratio of heart failure stratified by cumulative dose of prednisolone, NSAID or ULTs therapy.
| Medication exposed | N | Event | Person-year | Rate# | Adjusted HR† (95% CI) † |
|---|---|---|---|---|---|
| Prednisolone# | |||||
| Non-prednisolone | 51,455 | 1,740 | 366,166 | 4.75 | 1.00 |
| ≤300 mg | 60,942 | 1,919 | 451,277 | 4.25 | 0.77 (0.73, 0.83)*** |
| >300 mg | 38,101 | 1,630 | 283,891 | 5.74 | 0.61 (0.56, 0.66)*** |
| NSAID# | |||||
| Non-NSAID | 5,872 | 174 | 37,624 | 4.62 | 1.00 |
| ≤28,500 mg | 69,409 | 2,147 | 493,353 | 4.35 | 0.70 (0.60, 0.82)*** |
| >28,500 mg | 75,217 | 2,968 | 570,357 | 5.20 | 0.45 (0.38, 0.53)*** |
| ULTs | |||||
| Non-ULTs | 123,162 | 3,945 | 885,551 | 4.45 | 1.00 |
| ≤1,200 mg | 2,328 | 146 | 17,510 | 8.34 | 1.93 (1.63, 2.27)*** |
| >1,200 mg | 25,008 | 1,198 | 198,272 | 6.04 | 1.13 (1.05, 1.20)*** |
#, the cumulative dose is partitioned in to 2 segments by median; rate#, incidence rate, per 10,000 person-years; adjusted HR†, multiple analysis including age, sex, and comorbidities of diabetes, hypertension, hyperlipidemia, chronic kidney disease, stroke, chronic obstructive pulmonary diseases, asthma, alcohol-related illness, and coronary artery disease and medication of prednisolone and NSAID. ***P<0.001. PY, person-years; NSAID, nonsteroid anti-inflammatory drug; ULT, urate lowering theraphy.