Table 3. Univariate analysis and multivariate analysis the association of different variables with disease-free survival.

Variables	Univariate analysis			Multivariate analysis
	HR (95% CI)	P value		Adjusted HR (95% CI)	P value
Leukocytosis	1.544 (1.282, 1.859)	<0.001		1.417 (1.176, 1.707)	<0.001
Gender (male)	1.339 (1.151, 1.594)	0.001		0.961 (0.696, 1.381)	0.705
Age (≥65 years)	0.816 (0.535, 1.192)	0.167		NA
Tumor depth (T3–T4)	3.046 (2.758, 3.364)	<0.001		2.635 (1.658, 3.713)	<0.001
Lymph node metastasis (N2–N3)	4.506 (4.050, 5.014)	<0.001		2.655 (2.287, 3.083)	<0.001
Tumor stage (III–IV)	6.401 (5.735, 7.144)	<0.001		5.352 (4.593, 6.236)	<0.001
Tumor location (middle)	0.872 (0.650, 1.025)	0.375		NA
Tumor type (adenocarcinoma)	1.057 (0.754, 1.385)	0.653		NA
Tumor differentiation (poor)	1.575 (1.057, 2.068)	0.021		2.015 (1.604, 2.547)	<0.001
Surgical procedure (open)	4.051 (3.137, 4.934)	<0.001		2.304 (1.486, 3.211)	<0.001
Postoperative chemotherapy (no)	4.237 (3.248, 5.134)	<0.001		1.341 (1.124, 1.567)	0.012
Anesthesia (general and epidural)	0.848 (0.346, 1.331)	0.891		NA
Number of incisions [2]	1.021 (0.761, 1.314)	0.549		NA