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. 2020 May 8;11:2261. doi: 10.1038/s41467-020-16203-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a The transition probability matrices summarizing the likelihood from one grooming phase to another phase in the six grooming models. The different phases of no grooming/grooming activities were defined as no grooming (phase 0), paw licking (phase 1), nose/face/head grooming (phase 2), body grooming (phase 3), leg grooming (phase 4) and tail/genital grooming (phase 5). The numbers show the occurrence in % and are colour-coded. b, c The correlation coefficients b, and Euclidean distances c between each pair of transition probability matrices were derived. Hierarchical clustering analysis supports a higher similarity of the optogenetics model and the restraint and light models. RS body restraint stress, OS optogenetics stimulation of LSv, LS bright light exposure, ST spontaneous grooming, WS water spray, SM swimming. d The patterns and microstructures of six grooming models summarized by the phase transition probability matrix shown in a were transformed into two-colour binary format using a threshold of 25% illustrating higher similarity among the optogenetics model, the restraint model and the light model.