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. 2020 May 8;11:2294. doi: 10.1038/s41467-020-16213-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a DNA sequence (CAG) used for the structural study. b Structural superposition of the DNMT3A^R882H–CGA, DNMT3A^R882H–CGT and DNMT3A^R882H–CAG complexes, with the aligned catalytic loops, TRD loops and RD interfaces shown in expanded views. The side chains of the DNA-contacting residues are shown in stick representation. c–e van der Waals contacts between the catalytic loop (V716 and P718) and the nucleotide downstream of the methylation site (G6 or A6) in the DNMT3A^R882H–CGA (c), DNMT3A^R882H–CGT (d) and DNMT3A^R882H–CAG (e) complexes. f Close-up views of the interaction between TRD residue R836, with two alternative conformations, and the CAG DNA. The hydrogen-bonding interactions are shown as dashed lines.