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. 2020 May 8;10:7752. doi: 10.1038/s41598-020-64831-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) (Up) Representative image of biocytin-filled TrkC⁺ neuron. (Down) Representative image of neurons identified with a 63x water immersion objective and an infrared CCD camera during electrophysiological recording. They showed the typical morphology of large sensory pseudo-unipolar neurons. Time course analysis of electrophysiological excitability of differentiated neurons. (B) Representative traces of current-clamp recordings in cells at day 7 (left) 10 (middle) or 12 (right) of treatment with neurotrophic factors (days 15, 18, 20 of differentiation), in response to depolarizing current injection steps at 0 pA (lower trace) 20, 30 and 100 pA (higher trace). (C) Representative traces of current-clamp recordings in cells at day 12 of treatment with neurotrophic factors, in response to 0 (lower traces) 20, 30 and 100 pA (higher traces) of depolarizing current injection steps. Three different responses were observed: regular APs firing with firing frequency increasing for higher current injections (left); spontaneous activity with rapid accommodation following increasing step current injections (middle); single AP in response to higher injecting currents (right).