Table 4.
Comparison of Epidemiology and Risk Evaluations for Leukaemia, Brain Tumour and Lymphoma with our Study.
| Exclusion period (Year) | Database | Sample size | Age | Follow up period | Leukaemia result | Brain tumour result | Lymphoma result | |
|---|---|---|---|---|---|---|---|---|
| Pearce et al. (2012 retrospective cohort study) | 2 for Leukaemia; 5 for brain tumour | NHS, United Kingdom | 178,604 with Leukaemia; 176587 with brain tumour | 0–22 | 1985–2008 | ERR per mGy: 0.036 (95% CI 0.005–0120; p = 0.0097) | ERR per mGy: 0.023 (95% CI 0.010–0.049; p < 0.0001) | NA |
| Mathews et al. (2013 retrospective cohort study) | 1 | AIHW, Australia | 10,939,680 | 0–20 | 1985–2007 |
Leukaemias and myelodysplasias IRR: 1.23 (95% CI: 1.08–2.41) ERR per mGy: 0.039 (95% CI: −0.014–0.070) |
All CT scan: IRR: 2.13 (95% CI: 1.88–2.41); Only Brain CT: IRR: 2.44 (95% CI: 2.12–2.81) ERR per mGy: 0.029 (95% CI: −0.023–0.037) |
Hodgkin’s lymphoma IRR: 1.15 (CI:1.01–1.32); Other lymphoma IRR: 1.01 (CI: 0.82–1.23) |
| Huang et al. (2014 retrospective cohort study) | 2 | NHIRD, Taiwan | 122,086 | 0–18 | 1998–2008 | HR: 1.90 (95% CI: 0.82–4.40) | All brain tumour HR: 2.56 (95% CI: 1.44–4.54; p < 0.01); Malignancy HR: 1.84 (95% CI: 0.64–5.29) | NA |
| Journy et al. (2015 retrospective cohort study) | 1 | 23 department, France | 67,274 | 0–10 | 2000–2010 | ERR per mGy: 0.014 (95% CI: −0.037–0.065) | ERR per mGy: 0.017 (95% CI: −0.010–0.044) | ERR: −0.002 (95% CI: −0.050–0.046) |
| 2 | ERR per mGy: 0.047 (95% CI: −0.065–0.159) | ERR per mGy: 0.012 (95% CI: −0.013–0.037) | ERR: 0.008 (95% CI: −0.057–0.073) | |||||
| Krille et al. (2015 retrospective cohort study) | 2 | GCCR, Germany | 44,584 | 0–15 | 1980–2010 | SIR: 1.72 (95% CI: 0.89–3.01) | SIR: 1.35 (95% CI: 0.54–2.78) | SIR: 3.26 (95% CI: 1.63–5.83) |
| Li et al. (2020 retrospective cohort study) | 1 | NHIRD, Taiwan | 126,677 | 0–16 | 1998–2013 | OR: 1.04(95% CI: 0.72–1.48) | OR: 1.95 (95% CI:1.40–2.71, P < 0.001) | OR: 1.42 (95% CI: 0.78–2.59) |
| 2 | OR: 0.85 (95% CI: 0.54–1.34) | OR: 1.56 (95% CI:1.04–2.33, P = 0.031) | OR: 0.93 (95% CI: 0.42–2.05) |
Abbreviations: NHS = National Health Service; AIHW = Australian Institute of Health and Welfare; NHIRD = National Institutes of Health research database;
GCCR = German Childhood Cancer Registry; RR = risk ratio; HR = hazard ratio; ERR = excess relative risks; OR = odds ratio; SIR = standardized incidence ratios; NA = not available; 95% CI = 95% confidence interval.