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. 2020 May 8;10:7780. doi: 10.1038/s41598-020-64622-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduction ratios of middle molecules. (a) Reduction ratio at baseline. (b) Reduction ratio at 12 weeks after randomization. At baseline, all patients used a high-flux membrane. The error bars indicate the standard error. The specifications of the MCO and high-flux dialyzers are as follows (dialyzer [type of dialyzer, membrane polymer, inner diameter, wall thickness, effective surface area]): Theranova 400 (medium cut-off, polyarylethersulfone-PVP, 180 μm, 35 μm, 1.7 m²); FX CorDiax 80 (high-flux, polysulfone-PVP, 185 μm, 35 μm, 1.8 m²); FX CorDiax 60 (high-flux, polysulfone-PVP, 185 μm, 35 μm, 1.4 m²), respectively. Abbreviations: MCO, medium cut-off; FX80, FX CorDiax 80; FX60, FX CorDiax 60; β2-MG, β2-microglobulin; κFLC, kappa free light chain; λFLC, lambda free light chain; PVP, polyvinylpyrrolidone.