Table 2.
Univariate Analysis by Cox Regression
| Variable | Hazard ratio (95% confidence interval) | P value |
|---|---|---|
| Age | 1.084 (1.047–1.123) | < 0.0001 |
| Male sex | 1.082 (0.557–2.104) | 0.816 |
| BMI | 1.023 (0.974–1.074) | 0.3673 |
| Diabetes mellitus | 2.831 (1.417–2.657) | 0.003 |
| HgbA1c | 1.531 (1.217–1.926) | 0.0003 |
| Serum creatinine | 3.498 (0.648–18.875) | 0.1454 |
| WBC count | 0.940 (0.803–1.099) | 0.4365 |
| Neutrophil count | 0.999 (0.9997–1.000) | 0.7391 |
| Lymphocyte count | 0.999 (0.998–1.000) | 0.154 |
| Neutrophil/lymphocyte ratio | 0.996 (0.949–1.047) | 0.8874 |
| Monocyte count | 1.000 (0.999–1.002) | 0.6761 |
| Platelet count | 0.983 (0.979–0.988) | < 0.0001 |
| Total bilirubin | 5.407 (2.576–11.351) | < 0.0001 |
| ALP | 1.001 (1.000–1.003) | 0.0605 |
| GGT | 1.001 (0.998–1.004) | 0.6634 |
| AST | 1.004 (0.999–1.009) | 0.1533 |
| ALT | 1.001 (0.996–1.006) | 0.7791 |
| AST/ALT ratio | 1.713 (1.075–2.730) | 0.023 |
| Serum Albumin | 0.354 (0.193–0.649) | 0.0008 |
| Prothrombin time | 2.067 (0.947–1.204) | 0.285 |
| Serum transferrin | 1.018 (0.988–1.049) | 0.245 |
| Serum ferritin | 1 (0.998–1.001) | 0.9205 |
| APRI index | 1.678 (1.316–2.140) | <0.0001 |
| NAFLD fibrosis score | 1.306 (1.080–1.580) | 0.006 |
BMI: body mass index; HgbA1c: hemoglobin A1c; WBC: white blood cell; ALP: alkaline phosphatase; GGT: gamma-glutamyl transferase; AST: aspartate aminotransferase; ALT: alanine aminotransferase, APRI: AST-to-platelet ratio index; NAFLD: non-alcoholic fatty liver disease