Table 1.
Histomorphometric effects of Sr for different doses and calcium diets. At pharmacological doses and normal/supplemented calcium diets, Sr has not been shown to have a significant anabolic effect.
| Article | Subject | Form of Sr | Sr dose (mg/kg/day) | Duration of treatment | Calcium diet | Effects |
|---|---|---|---|---|---|---|
| Marie et al. (1985) | WT Rat | SrCl2 | 316, 633.7 | 9 weeks | 0.50% | ↑ trabecular bone density and calcified bone growth (316 dose) ↓ serum calcium and 1,25-D, induced defective mineralization (633.7 dose) |
| Morohashi et al. (1994) | WT Rat | SrCO3 | 510 | 27 days | 0.50% | ↑ trabecular bone volume ↓ bone formation, bone resorption, calcium content in bone (−20%) and serum calcium |
| Marie and Hott (1986) | WT Rat | SrCl2 | 350 | 29 days | 0.50% | No significant effect on bone volume or bone mineral content ↑ osteoid surface by 10% ↓ number of active osteoclasts by 11% |
| Grynpas et al. (1996) | WT Rat | omitted | 168 | 8 weeks | 0.50% | ↑ mineral bone volume by 17% ↑ number of bone-forming sites by 70%, with no adverse effect on mineralization |
| Grynpas and Marie (1990) | WT rat | SrCl2 | 316, 633.7 | 8 weeks | 0.50% | ↑ osteoid volume and bone mass with no effect on bone volume ↑ bone volume and parameters of bone formation, accompanied by defective bone mineralization |
| Ammann et al. (2004) | WT rat | SrRan | 225, 450, 900 | 2 years | 0.76% | ↑ bone volume (625 and 900 doses) ↑maximal load (900 dose only) |
| Morohashi et al. (1995) | OVX Rat | SrCO3 | 50 | 2 weeks | 0.50% | ↓bone formation and bone resorption, but not completely back to sham levels. No change in bone volume in any group. |
| Marie et al. (1993) | OVX Rat | SrRan | 77, 154, 308 | 2 months | 0.60% | ↑ bone volume by 30–36% ↓ osteoclast number/ surface no effect on osteoblast surface/number |
| Fuchs et al. (2008) | OVX Rat | SrRan | 25, 150 | 90 days | 0.1% or 1.19% (normal) | No effect on bone volume, bone formation observed for either dose or calcium diet ↑ serum Sr and Sr accumulation in bone for low calcium diet |
| Arlot et al. (2007) | Biopsies from PREVOS, STRATOS, SOTI and TROPOS | SrRan | 25 | 1–5 years |
Normal +500 mg/day | ↑ BMD and ↓ new fractures for all clinical trials ↑osteoblast surface and osteoid thickness no effect on bone resorption was observeda |
| Chavassieux et al. (2014) | Post-menopausal osteoporotic women | Sr-Ran | 25 | 6–12 months | Normal +1000 mg/day | ↓ mineralizing surface/bone surface (MS/BS) no effect on resorption ↓ bone volume, trabecular thickness and trabecular number |
↑ Increase ↓ Decrease
a
Only 4 paired treatment biopsies and 1 paired placebo biopsy performed.