Table 1.
Summary of Clinical Trials Using Pexidartinib
| NCI Identifier | Phase | Setting | Recruitment Status | Combined Treatments |
|---|---|---|---|---|
| NCT02071940 | II | KIT-mutated advanced acral and mucosal melanoma | Unknown | |
| NCT02975700 | I, II | Unresectable or metastatic KIT-mutated melanoma | Active, not recruiting | |
| NCT01499043 | II | Advanced castration-resistant prostate cancer with bone metastasis and high circulating tumor cell counts | Terminated | |
| NCT01349036 | II | Recurrent glioblastoma | Terminated | |
| NCT02390752 | I, II | Refractory leukemias and refractory solid tumors, including neurofibromatosis type 1-associated plexiform neurofibromas | Recruiting | |
| NCT01217229 | II | Relapsed or refractory Hodgkin lymphoma | Completed | |
| NCT01349049 | I, II | Relapsed or refractory FLT3-ITD-positive acute myeloid leukemia | Completed | |
| NCT01004861 | I | Advanced, incurable solid tumors in which the target kinases are linked to disease pathophysiology | Active, not recruiting | |
| NCT02371369 | III | Pigmented villonodular synovitis (PVNS) or giant cell tumor of the tendon sheath (GCT-TS) | Active, not recruiting | |
| NCT04223635 | I | Symptomatic tenosynovial giant cell tumor (in setting of hepatic impairment) | Recruiting | |
| NCT02734433 | I | Asian subjects with advanced solid tumors | Active, not recruiting | |
| NCT02777710 | I | Metastatic/advanced pancreatic or colorectal cancers (MEDIPLEX) | Active, not recruiting | Durvalumab |
| NCT02452424 | I, II | Advanced melanoma and other solid tumors | Terminated (Terminated early for insufficient evidence of clinical efficacy) | Pembrolizumab |
| NCT01790503 | I, II | Newly diagnosed glioblastoma | Active, not recruiting | Radiation therapy, Temozolomide |
| NCT01525602 | I | Advanced solid tumors | Completed | Paclitaxel |
| NCT01596751 | I, II | Metastatic breast cancer | Active, not recruiting | Eribulin |
| NCT02584647 | I, II | Unresectable sarcoma and malignant peripheral nerve sheath tumors | Recruiting | Sirolimus |
| NCT02401815 | I, II | Advanced gastrointestinal stromal tumor (GIST) | Active, not recruiting | PLX9486 |
| NCT01826448 | I | Unresectable or metastatic melanoma | Terminated | Vemurafenib |
| NCT01042379 | II | Breast cancer | Recruiting | Paclitaxel |
| NCT02472275 | I | Prostate adenocarcinoma | Suspended (Safety Review) | Radiation therapy, Antihormone therapy |
| NCT03158103 | I | Advanced gastrointestinal stromal tumor (GIST) | Active, not recruiting | MEK162 |