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. 2020 Jan 17;10(1):23–42. doi: 10.1016/j.jcmgh.2020.01.005

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Gene expression analysis of Atf2^wt/wtAtf7^+/+and Atf2^-/-Atf7^ko/koorganoids. (A) Principal component analyses (PCA) on global gene expression in Atf2^wt/wtAtf7^+/+ and Atf2^-/-Atf7^ko/ko organoids at baseline and after 12 hours of TNF-α stimulation (n = 4 independent organoid cultures). (B) Venn diagram showing significantly up-regulated genes between Atf2^wt/wtAtf7^+/+ and Atf2^-/-Atf7^ko/ko after TNF-α stimulation. (C) Curated heat maps of 99 up-regulated genes specific for Atf2^-/-Atf7^ko/ko organoids. Highlighted genes were chosen based on biological interest. The colored bar represents the z-score–transformed expression level from low (red) to high (green). (D) Significantly altered GO pathways between Atf2^wt/wtAtf7^+/+ and Atf2^-/-Atf7^ko/ko organoids on TNF-α stimulation.