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Proposed kinetic model for ChuY and experimental validation. (A) ChuY follows a random association kinetic model with a kinetic preference for NADPH binding. (B) DAB saturation kinetics were performed as described in the legend of Figure 6E using approximately 200 μM NADPH. The rates were plotted with respect to DAB concentration and fit to the equation for substrate inhibition (eq 2). (C) Residual analysis was used to assess the fit of the data.
