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. 2020 Apr 30;2020:5691671. doi: 10.1155/2020/5691671

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Copyright © 2020 Pengfei Sun et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

RAB9A promotes the malignant behavior of liver cancer cells by activating the AKT/mTOR signaling pathway. AKT signaling pathway components were detected (a) and quantified (b) by western blot. (c) Cell proliferation of Hep3b cells was detected by CCK8 assay. (d) The invasion of Hep3b cells was determined by transwell assay. OV: overexpression of RAB9A; OV+BEZ235: overexpression of RAB9A+treatment of double-effect inhibitor (BEZ235) which inhibits AKT and mTOR phosphorylation. ^∗P < 0.05.