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. 2020 Apr 30;2020:5939530. doi: 10.1155/2020/5939530

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Copyright © 2020 Shao-Hong Wu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

PTEN/Akt and GTPCH/BH4 pathway blockade inhibits in vitro function of EPCs treated with LSS. Quantification analysis of migration (a), proliferative activity (b), and tube formation (represented as relative value to EPCs under static condition group) of late EPCs (c) of EPCs treated with GTPCH I knockdown and Akt inhibition (^∗P < 0.05 vs. EPCs under static condition group, n = 6; ^#P < 0.05 vs. LSS+EPC group, n = 6 per group). Least significant difference was applied for the post hoc test in statistical analysis. Concentration of LY 294002: 10 μmol/l. LSS = laminar shear stress.