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. 2020 Apr 30;2020:5939530. doi: 10.1155/2020/5939530

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Copyright © 2020 Shao-Hong Wu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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PTEN/Akt and GTPCH/BH4 pathway blockade inhibits in vivo angiogenesis of EPCs treated with LSS. Representative photographs (a) and quantification analysis showing in vivo angiogenesis capacity of EPCs treated with GTPCH I knockdown and Akt inhibition for improving blood perfusion in ischemic hind limb (b, c) (^∗P < 0.05 vs. medium, n = 6; ^#P < 0.05 vs. EPCs under static condition group, n = 6; ^&P < 0.05 vs. LSS+EPC group, n = 6 per group). Least significant difference was applied for the post hoc test in statistical analysis. Concentration of LY 294002: 10 μmol/l. (d) Representative photographs and quantification analysis showing in vivo angiogenesis capacity of EPCs by CD31 staining (^∗P < 0.05 vs. medium, n = 6; ^#P < 0.05 vs. EPCs under static condition group, n = 6; ^&P < 0.05 vs. LSS+EPC group, n = 6 per group). Scale bar 50 μm. Concentration of LY 294002: 10 μmol/l. LSS = laminar shear stress; hpf = high power field.