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Hydrolysis half-lives of ester linkers between 8-arm PEG and carboxylated derivatives of Dex. Molar ratio of Dex conjugated with PEG for each configuration and the corresponding drug loading content (DLC). Data shown as Mean ± SD.
| Ester linker | PEG-Dex-SA | PEG-Dex-GA | PEG-Dex-PA | PEG-Dex (2:1:1) |
|---|---|---|---|---|
| Half-life (h) | 6.8 ± 0.2 | 79 ± 1.8 | 86 ± 2.3 | 38.5 ± 1.5 |
| Dex: PEG (molar ratio) | 6.6 ± 0.5:1 | 1.6 ± 0.4:1 | 3.3 ± 0.5:1 | 4.6 ± 0.5:1 |
| DLC (%) | 15.70 ± 1.0 | 3.81 ± 0.9 | 7.85 ± 0.1 | 11.1 ± 0.8 |
