Fig. 5.

IGF2BPs enhances DTX3L mRNA stability via an m⁶A-dependent manner. a The mRNA half-life of DTX3L transcript in IGF2BP1 and (b) IGF2BP3 depletion endothelial cells, respectively. c-d) qRT-PCR and (e) western blot analysis of the expression level of specific genes in control and IGF2BP3 deficient cells. f Effects of IGF2BP3 on migration and (g) tube formation of endothelial cells. Data are shown as mean ± SEM of three independent experiments. P values were calculated using Student’s t-test. *, P < 0.05; **, P < 0.01; ***, P < 0.001