Table 1.
Statistically significant correlations detected for individual proteins quantified at different disease Braak stages in brain extracellular vesicles (EVs) and remaining brain tissues
| Protein gene symbol | Correlated variables | Correlation coefficient* | p value | Potential interpretation** | |
|---|---|---|---|---|---|
| MAG | AD5 WB | AD6 EVs | 0.99 | 0.040 | Degradation by EVs |
| GMFB | AD3 WB | AD4 EVs | 0.99 | 0.048 | Preclinical and early symptomatic rescue response in EVs |
| AD3 WB | AD6 EVs | 0.99 | 0.049 | – | |
| GABARAPL | AD3 WB | AD3 EVs | 0.99 | 0.041 | – |
| AD3 EVs | AD4 WB | 1.00 | 0.003 | Preclinical encapsulation in EVs | |
| AD3 EVs | AD5 WB | 1.00 | 0.013 | Preclinical encapsulation in EVs | |
| AD3 EVs | AD6 EVs | 0.86 | 0.003 | Abnormal uptaking late stage AD | |
| Lamp1 | AD3 EVs | AD4 WB | 0.99 | 0.039 | Ongoing Lamp1 synthesis during AD progression. Abnormal Lamp1 inclusion in lysosomes in AD progression |
| AD3 EVs | AD5 WB | 1.00 | 0.020 | ||
| AD3 EVs | AD6 WB | 0.99 | 0.036 | ||
| GAP43 | AD3 WB | AD4 EVs | 0.99 | 0.046 | Preclinical and early symptomatic rescue response in EVs |
Correlations were calculated based on abundance of proteins identified in brain EVs and remaining brain tissues
*Refers to Pearson correlation coefficient
**Plausible interpretation of the protein role(s) based on the correlated variables involved in each identified statistically significant interaction(s) (parallel analysis brain EVs versus remaining brain tissues)