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. 2020 May 9;17:153. doi: 10.1186/s12974-020-01810-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — RRMS sera induce an altered mitochondrial respiration in ECs. a Kinetic profile of OCR in hCMEC/D3 cells treated overnight with 20% HD or RRMS naïve-to-treatment sera. Real time OCR was measured, under basal conditions and in response to oligomycin, FCCP, Antimycin A and Rotenone. Indices of mitochondrial respiratory function, calculated from hCMEC/D3 OCR profile: basal and maximal respiration (b, e), ATP production (c), proton leak (d) and spare capacity (f). Graphics are a cumulative data performed on 10-15 donors/group, matched in sex, age and EDSS score. Data are shown as mean ± s.e.m. (statistical analysis by Mann-Whitney U test (two-tails)*P ≤ 0.05, **P ≤ 0.01)