Table 2.
Clinical Progression
| Neurologic Clinical Symptomsa | Boxer |
Dachshund |
||||
|---|---|---|---|---|---|---|
| Prior ZIKVBR Treatment | After 1st ZIKVBR Dose (106 PFU) | After 2nd ZIKVBR Dose (107 PFU) | Prior ZIKVBR Treatment | After 1st ZIKVBR Dose (106 PFU) | After 2nd ZIKVBR Dose (107 PFU) | |
| Seizures | 3 per day | zero | 2 events | zero | zero | zero |
| Altered mental statusb | +++ | + | – | +++ | + | – |
| Circling to one side | +++ | + | – | – | – | – |
| Compulsive pacing | ++ | + | + | – | – | – |
| Abnormal gait and posture (ataxia and paresis) | – | – | – | +++ | + | – |
| Nasal sensitivity deficiency | – | – | – | ++ | ++ | – |
| Central blindness (cortical) | – | – | – | – | – | – |
| Pupillary size and symmetry deficiency | – | – | – | + | + | + |
| Pupillary reflexes | – | – | – | – | – | – |
| Palpebral reflexes | – | – | – | – | – | – |
| Contralateral menace deficit | R+++ | R+ | R+ | L+ | L– | L– |
| Contralateral decreased conscious perception | R +++ | R+ | R+ | L+ | L– | L– |
| Contralateral facial sensation deficit | R+++ | R+ | R+ | L+/R+ | L+/R+ | L+/R+ |
a
The score system applied for each neurologic clinical symptom is as follows: (–) normal, (+) mild, (++) moderate, (+++) severe. The letters R and E stand for lateralization in each the neurologic lesion appear, either to the right or to the left side of the body, respectively.
b
Defined by 1 or more of the following clinical signs as follows: behavior change, dementia, dullness, and disorientation.