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. Author manuscript; available in PMC: 2020 May 9.
Published in final edited form as: Neuropharmacology. 2019 Jul 1;160:107690. doi: 10.1016/j.neuropharm.2019.107690

Fig. 4.

Fig. 4.

MMG22 did not produce acute tolerance to its analgesic effects when administered s.c. (A), i.m. (B). or orally (C). Anti-hyperalgesia peaked at 60–120 min after MMG22 and was just as effective when administered 24 h after the first administration. $ indicates a significant difference from baseline. * indicates a significant difference from pre-drug values. All comparisons were made using Bonferroni t-tests, p < 0.001).