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. Author manuscript; available in PMC: 2020 May 9.
Published in final edited form as: Brain Behav Immun. 2019 Mar 15;80:247–254. doi: 10.1016/j.bbi.2019.03.016

Fig. 2.

Fig. 2.

METH-induced cognitive decline is attenuated by mIL1T. Mice were treated as in Fig. 1, and spatial learning was evaluated by Morris water maze test four days after the last dose of METH. For the first five days (D1-D5; the learning phase of the test) the animals learned the location of the platform. Then, the reversal learning was applied (R1-R5) when the animals relearned a new location of the platform, testing cognitive flexibility. The statistical differences were observed in (A) latency to reach the platform and (B) proximity measure, suggesting that the experimental groups differed in spatial learning abilities. (C) Exposure to METH and/or mIL1T did not affect swimming speed of mice during the training period. All results were analyzed by two-way repeated measures ANOVA with Student Newman-Keuls test; mean ± S.E.; n = 8; *p < 0.05, **p < 0.01, ***p < 0.001).