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. 2020 May 8;11:2272. doi: 10.1038/s41467-020-16145-4

Fig. 6. Summary of the work.

Fig. 6

a Primary sequence representation of the minimal lactazole scaffold with the outcomes of the Lys, Glu, MeGly, and MeAla-scanning experiments mapped to the resulting consensus sequence. b Chemical structure representation of the minimal lactazole scaffold. ce Structural diversity of thiopeptides accessible with the FIT-Laz system. Displayed are chemical structures of the smallest artificial lactazole c, thiopeptide with the largest macrocycle d, and the largest construct e synthesized in this work.