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. 2020 May 8;10:7826. doi: 10.1038/s41598-020-64832-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PGE₂ production in cUC cells (Sora) during drug screening. (A) Y axis represents log 10 values of changes in PGE₂ production for each inhibitor (n = 331). The drugs which belong to selected pathways are coloured as indicated. (B) Visualisation and comparison of the results from drug screening for PGE₂ production and cell growth⁵². Drugs which showed ≥50% reduction in PGE₂ production and cell density were included in statistical analysis. Categories which have more than 3 inhibitors are presented in this graph. Node size represents proportion of the drugs which showed reduction more than the threshold in each category. Colour represents statistical significance.