Fig. 6. Major DNA repair processes involved in the rejoining of the breakpoints after chromothripsis.

Based on the number of base pairs of homology at the breakpoint sites, we can infer the prevailing repair processes involved in the rejoining of the DNA fragments (a–f). Statistical significance was tested using beta-regression analyses. Family-wise correction of p values was performed according to Bonferroni for all tumour entities with at least 15 cases in total, of which at least 5 tumours showed chromothripsis and at least 5 were negative. The comparisons shown here were performed case wise (tumours with versus without chromothripsis). Comparisons performed region wise (chromothriptic chromosomes versus non-chromothriptic chromosomes) are shown in Supplementary Fig. 6. Centre lines show median values, bounds of boxes show 75th percentiles and whiskers show maximum and minimum. (*p < 0.05; **p < 0.01; ***p < 0.001).