Fig. 8. Longitudinal analysis of chromothriptic patterns in matched primary-relapse pairs and different metastases from the same patients.

Representative examples of the evolution of chromothriptic patterns are shown. Analyses of the evolution of chromothriptic patterns for all matched pairs (n = 41, with 24 pairs showing chromothripsis) are shown in Supplementary Data 5. Example 2 is from a different patient cohort because examples for this specific scenario with available whole-genome sequences for both time points were lacking. Blue lines indicate inversions, green lines indicate break ends, brown lines indicate translocations and orange lines indicate copy-number variation.