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. 2020 May 8;10:7760. doi: 10.1038/s41598-020-64722-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolome compositions differ strongly for both cell type and insult severity. (a) Principal component analysis of the metabolomes of AC (circles) and EC (squares) exposed to normoxia, hypoxia and near anoxia in presence and absence of glucose. Axes represent the first three principal components (PC) of the dataset and their contribution to overall metabolome variance in percent (%). (b) Correlation matrix plot of all AC and EC conditions. The Pearson correlation coefficients were calculated by log2 transformed ratios of the median values of fold changes and are represented by gradient colors as indicated in the color key. Correlations less than 0.6 are shown in gray. (c) Hierarchical clustering heatmap of different injury conditions in AC and EC samples. Metabolites significantly decreased are displayed in green and those significantly increased displayed in red. The brightness of each color corresponds to the magnitude of the difference when compared with average values. Normoxia (NX), hypoxia (HX) and near anoxia (AX) in presence and absence of glucose (±Glc). To enable comparison of data between the cell types, the metabolite intensities were normalized to total ion counts. n = 4.