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. 2020 May 8;10:7818. doi: 10.1038/s41598-020-64902-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pemafibrate improves inflammatory genes expression in STAM mice liver. (A) Heatmap showing changes in expression of selected 74 genes. (B) qPCR validation of myeloid cell marker and inflammatory genes in the liver (n = 6). Immunoblot of Vcam1 protein is shown in upper boxed panel. Error bars show s.e.m. *P < 0.05; **P < 0.01. (C) HUVECs were cultured and treated with DMSO or pemafibare for 24 h in the presence of 50 mM Glucose. qPCR validation of PDK4 and VCAM1 expression (n = 3). Error bars show s.e.m. *P < 0.05; **P < 0.01: Significantly difference from STAM control group by Dunnett’s multiple comparison test.