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. 2020 May 8;10:7805. doi: 10.1038/s41598-020-64703-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Study design. n = 4♀ (P HM B6/MM B6/MM SW); 8♀, 12♂ (F1 HM B6); 14♀,12♂ (F1 MM B6); and 25♀,19♂ (F1 MM SW) (see Table 1). Germ-free B6 and SW mice were transplanted when six weeks old with HM or B6 MM and housed in gnotobiotic isolators. The transplanted P mice were bred and the offspring (F1) generation born with the microbiota (related to Table 1). (b) Colonization efficiency. The proportion of operational taxonomic units (OTUs) from the human and mouse donor samples that were detected in the recipient P and F1 mice is shown. The outermost non-filled circle represents the donor samples, i.e., 100%. Each smaller circle represents fecal samples sorted generation- and age-wise and with standard deviation. From left to right: HM donor and B6 recipients; B6 MM donor and B6 recipients; B6 MM donor and SW recipients. HM = human microbiota, MM = mouse microbiota, B6 = C57BL/6NTac, SW = Tac:SW (Swiss Webster), P = transplanted parent generation, F1 = offspring generation born with microbiota.