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. 2020 Mar 31;105(7):e2563–e2571. doi: 10.1210/clinem/dgaa168

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© Endocrine Society 2020.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Results of the multiple-dose MTP in patients with Prader–Willi syndrome. N = 46. A: Relation between baseline cortisol (nmol/L) and 11-deoxycortisol (nmol/L). Spearman’s rho was 0.16 (P = 0.28). Even patients with low baseline cortisol had normal 11-deoxycortisol levels. B: Relation between ACTH (pmol/L) after metyrapone administration and 11-deoxycortisol (nmol/L). Spearman’s rho was 0.35 (P = 0.02). The dotted line represents the cutoff of 33 pmol/L used by the Dutch pediatric study (12), which would falsely classify 21 patients with sufficient increase in 11-deoxycortisol levels as “adrenal insufficient.”