Table 3.
Results of the insulin tolerance test
| Baseline Cortisol (nmol/L) | Peak Cortisol (nmol/L) | Glucose (mmol/L) a | Baseline ACTH (pmol/L) | Peak ACTH (pmol/L) | Delta ACTH (pmol/L) b | CAI Cutoff (nmol/L) c | |
|---|---|---|---|---|---|---|---|
| France (n = 10) | |||||||
| Median | 229.0 | 735.5 | 1.6 | N/A | N/A | N/A | <500 |
| Range | 102.0–384.0 | 494.0–1021.0 | 0.6–2.2 | N/A | N/A | N/A | |
| The Netherlands (n = 10) | |||||||
| Median | 233.0 | 702.0 | 1.9 | 3.3 | 61.2 | 57.1 | <500 |
| Range | 119.0–502.0 | 530.0–883.0 | 1.4–2.4 | 1.1–6.2 | 23.8–93.5 | 21.2–90.5 | |
| Sweden (n = 6) | |||||||
| Median | 185.5 | 722.5 | 1.7 | N/A | N/A | N/A | <500 |
| Range | 175.0–265.0 | 502.0–822.0 | 1.2–2.6 | N/A | N/A | N/A | |
| UK (n = 10) | |||||||
| Median | 172.5 | 522.5 | 1.5 | 3.7 | N/A | N/A | <450 |
| Range | 93.0–545.0 | 455.0–971.0d | 1.0–2.1 | 1.7–6.4 | N/A | N/A |
Abbreviations: CAI, central adrenal insufficiency; N/A, not available.
a Two patients had glucose levels of 2.4 mmol/L and 2.6 mmol/L, respectively. All other patients had glucose levels ≤ 2.2 mmol/L. b Increase in ACTH after insulin administration. c Peak cortisol cutoff for diagnosis of CAI. One French patient had peak cortisol < 500 nmol/L. d In the UK, the cutoff for CAI is 450 nmol/L (see also: methods).