. Author manuscript; available in PMC: 2020 May 9.

Published in final edited form as: Int J Cancer. 2018 Dec 6;144(10):2401–2407. doi: 10.1002/ijc.31966

Table 3.

Odds ratios and 95% confidence intervals of advanced prostate cancer by combined categories of total 25-hydroxyvitamin D and vitamin D binding protein¹

		Total 25(OH)D²		p_interaction
		Low (<24.3 ng/mL)	High (≥24.3 ng/mL)	p_interaction
VDBP²	Low (<239.8 µg/mL)	0.81 (0.42–1.59)	0.81 (0.38–1.74)	0.03
	High (≥239.8 µg/mL)	1	0.31 (0.15–0.65)

Abbreviations: 25(OH)D, 25-hydroxyvitamin D; CI, confidence interval; OR, odds ratio; VDBP, vitamin D binding protein.

OR (95% CI) from conditional logistic models conditioned on matching factors and adjusted for family history of prostate cancer, body mass index (<25.0, 25.0–29.9, ≥30.0 kg/m²), vigorous physical activity (0, 0.1–5.9, 6.0–12.9, 13.0–25.9, ≥26.0 metabolic equivalent-h/week), and smoking status (never, past, current).

Cutpoints chosen based on median values in controls: 56 cases and 46 controls with low total 25(OH)D levels and low VDBP levels; 42 cases and 31 controls with low total 25(OH)D levels and high VDBP levels; 32 cases and 31 controls with high total 25(OH)D levels and low VDBP levels; 25 cases and 47 controls with high total 25(OH)D levels and high VDBP levels.