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. 2020 Apr 20;69(8):1543–1544. doi: 10.1136/gutjnl-2020-321388

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Increased FC and serum IL-6 feature acute diarrhoea in COVID-19. (A) FC concentration determined by ELISA. Group A (n=18): COVID-19 patients without diarrhoea. Group B (n=13): COVID-19 patients who reported diarrhoea which ceased 48 hours before stool collection. Group C (n=9): COVID-19 patients with acute diarrhoea (onset <48 hours) (*p<0.001, group B versus group A; **p<0.001, group C versus groups B and A). (B) Correlation of serum IL-6 concentration with FC concentration reported in A. (C) Detection of faecal SARS-CoV-2-RNA by PCR, reported as 1/cycle threshold value. Dashed line indicates threshold of RNA detection. (D) Correlation of faecal SARS-CoV-2-RNA (as in C) with FC. COVID-19, coronavirus disease 2019; FC, faecal calprotectin; IL-6, interleukin-6; SARS-CoV-2, severe acute respiratory syndrome corona virus 2.