Table 6. ECM-related gene expression of primary chondrocytes after DEX exposure.

+ denotes an increase, − a decrease and = no change from control. James et al. (2007) used an ECM gene set from the Gene Set Enrichment Analysis (GSEA) database (Subramanian et al., 2005).

Authors	Year	Cell type	DEX dose	Duration	Effect on RNA expression
Song et al.	2012	Human	20–200 μM	24 h-1 week	− ACAN, − collagen II
James et al.	2007	Mouse	100 nM	24 h	+ ECM genes
Richardson and Dodge	2003	Equine	10 nM–1 μM	24 h	− collagen II, − MMP13, − MMP1, − MMP3, + fibronectin