Table 2.

Serum alanine transaminase (ALT) levels in young and old male and female GH-overexpressing transgenic mice and normal controls.

Plasma ALT (U/L)	Young adult (n=17–21)	Old (n=27–31)
Normal females	16 ± 3 a	15 ± 2 a
Normal males	14 ± 2 a	16 ± 2 a
Transgenic females	39 ± 3 b	61 ± 5 b *
Transgenic males	47 ± 4 b	86 ± 5 c **

Data are the mean ± SEM of the indicated number (n) of different individuals per group. Different letters denote significant differences between normal and GH-transgenic, male and female mice, assessed by two-way ANOVA (P<0.05). Asterisks indicate significant differences between young and old animals of the same sex and genotype by unpaired Student’s t-test.

^*P<0.05,

^**P<0.01.